Apple Thoughts: Help For Those Safari Hangs

"Sometimes-especially when you have a lot of tabs open and a lot of pages running Flash-Safari can hang to the point where it needs a restart. Unfortunately, restarting Safari can be inconvenient."

This is, of course, only if you are comfortable with using Terminal. It involves manually stopping the WebKitPluginHost process, so once Safari notices that the process has ended, it restarts it and refreshes the page that was using the Flash plug-n. This process will stop all plug-ins though, not just the Flash so they will also start back up once the page refreshes. I've been dealing with this issue recently so I may have to try this quick fix. To do it, open up Terminal (located in your Utilities folder in Applications, and type killall -9 WebKitPluginHost.